Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1a Expression
نویسندگان
چکیده
منابع مشابه
Isoflurane preconditioning increases survival of rat skin random-pattern flaps by induction of HIF-1α expression.
BACKGROUND Survival of random-pattern skin flaps is important for the success of plastic and reconstructive surgeries. This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this process. METHODS Human umbilical vein endothelial cells (HUVECs) and human skin fibroblast cells were exposed to isoflurane for 4 h. Expression o...
متن کاملExpression of endothelin 1 in rat random-pattern skin flaps treated with topical nifedipine.
OBJECTIVE To evaluate the relative tissue concentrations of the endogenous vasoactive peptide endothelin 1 (ET-1) in random-pattern skin flaps (RPSF) treated with either topical anti-ischemic drug therapy (nifedipine) or placebo. DESIGN Prospective, randomized, placebo-controlled therapeutic trial. SUBJECTS Adult male Sprague-Dawley rats. INTERVENTION Experimental subjects underwent cauda...
متن کاملThe Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats
BACKGROUND Partial or complete necrosis of a skin flap is a common problem. Polydeoxyribonucleotide (PDRN) can be extracted from trout sperm and used as a tissue repair agent. The aim of this study was to investigate whether PDRN could improve the survival of random pattern skin flaps in rats. METHODS Twenty-two male Sprague-Dawley rats were randomly divided into two groups: the PDRN treatmen...
متن کاملThe effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats
Objectives. One of the important causes of flap losses is ischemia-reperfusion damage. Arnebia species are rich in naphthoquinone derivatives which known to have anti-inflammatory and anti-oxidant effects. The aim of the present study was to investigate the effects of Arnebia purpurea extract on viability of the skin flaps. Methods. Eighteen Wistar rats were divided in three groups. Caudal-base...
متن کاملUse of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps.
BACKGROUND Skin flaps are commonly used in soft-tissue reconstruction; however, necrosis can be a frequent complication. Several systemic and local agents have been used in attempts to improve skin flap survival, but none that can prevent flap necrosis have been identified. AIMS This study aims to determine whether the use of systemic Rosmarinus officinalis (R. officinalis) extract can preven...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2013
ISSN: 1421-9778,1015-8987
DOI: 10.1159/000350078